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| behcet_disease [2026/02/04 22:27] – Scott Larson | behcet_disease [2026/02/04 22:46] (current) – [Etiology] Scott Larson | ||
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| ====== Behçet' | ====== Behçet' | ||
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| ====Main Features==== | ====Main Features==== | ||
| * Systemic Vasculitis characterized by recurrent oral ulcers (nearly all) with variable involvement of skin, eyes, joints, vascular system, GI tract and CNS | * Systemic Vasculitis characterized by recurrent oral ulcers (nearly all) with variable involvement of skin, eyes, joints, vascular system, GI tract and CNS | ||
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| * Panuveitis | * Panuveitis | ||
| ====Other Findings==== | ====Other Findings==== | ||
| - | * | + | * Skin, Mucosa and articular |
| + | * Oral ulcers 98% | ||
| + | * Genital ulcers 60-65% | ||
| + | * Skin lesions 75% | ||
| + | * pseudofoliculitis | ||
| + | * papulopustular lesions (acne-like) | ||
| + | * erytherma nodosum | ||
| + | * Arthralgia or arthritis 50% | ||
| + | * knees, ankles, wrists, and elbows | ||
| + | * enthesopathy | ||
| + | * CNS 10-30% | ||
| + | * Mesodiencephalic and brainstem inflammation | ||
| + | * Encephalitis | ||
| + | * Meningitis | ||
| + | * Myelitis | ||
| + | * Neurocognitive dysfunction | ||
| + | * Cerebral-vein thrombosis | ||
| + | * Cardiovascular | ||
| + | * Arterial 2-18% | ||
| + | * Artery aneurisms | ||
| + | * arterial stenosis or thrombosis | ||
| + | * Heart 6% | ||
| + | * Valvulitis | ||
| + | * Myopericarditis | ||
| + | * Coronary arteritis | ||
| + | * Venous 15-40% | ||
| + | * Deep vein thrombosis of limbs, pulmonary, suprahepatic | ||
| + | * Superficial thrombophlebitis | ||
| + | * GI 0-20% | ||
| + | * Mucoasal ulcers | ||
| + | * Abdominal pain | ||
| + | * Hemorrhage and/or perforation | ||
| ====Etiology==== | ====Etiology==== | ||
| - | * | + | * Genetically predisposed are exposed to environmental triggers leading to activation of cellular signally pathways leading to tissue inflammation and damage. |
| + | * HLA B*51 increases the risk by 6 | ||
| + | * Highest prevalence in Turkey: 420 cases per 100,000 | ||
| + | * US: 5.2 cases per 100, | ||
| ====Resources==== | ====Resources==== | ||
| - | * [[link|Title]] | + | * [[https:// |
| + | * [[https:// | ||
| {{tag> | {{tag> | ||